We have little information about some members of the Eleusinian priesthood. The Panageis Priest is known from epigraphic testimonies, but we know almost nothing about his responsibilities. We know that around 460 BCE he had the title “priest [Panageis]”. In 20/19 BCE the holder of the office was called “Panageis Priest”, and at the end of the third century CE the title was changed once again (“Priest of Panageis”). These changes may reflect new responsibilities, but we have no clear evidence. He probably came from the genos of the Kerykes and had an honorary position in the theatre of Dionysus. One of the most prominent Athenians of late antiquity, Publius Herennius Dexippus, who distinguished himself in defence of Attica from the barbarian invasion of the Heruli, was a Panageis Priest. Dexippus belonged to a prominent Athenian family. His uncle and grandfather had served as Kerykes, while he, in addition to Panageis Priest, served as agonothetes of the Panathenaic Games, Archon Basileus, and Eponymous Archon.

The Panageis priestesses had the right to handle the sacred objects, so perhaps they were responsible for transporting them to Athens and back to Eleusis as part of the celebration of the Greater Mysteries. They lived in a dedicated area in the sanctuary and did not mingle with men. Ancient sources often refer to them as “melisses”, while the title “Panageis” was often given to other priests and priestesses of Demeter. Unfortunately, we do not know the genos from which they came with absolute clarity.